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Pepperoni Pizza Meatloaf

This Pepperoni Pizza Meatloaf is a delicious ground beef meatloaf loaded with pizza seasonings, Pepperoni slices, and Italian bread crumbs, all wrapped around fresh mozzarella cheese and topped with warm pizza sauce.

Why I love this recipe

These meatloaves are very easy to make. We have also made enough for guests and everyone raves over them.

Pepperoni Pizza Meatloaf and a side of garlic bread.
Pepperoni Pizza Meatloaf

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Substitutions

  • Substitute ground chicken or ground turkey for the ground beef.
  • You can stuff the meatloaf with shredded mozzarella but it may not melt as smoothly as fresh.

Step 1 - Preheat the oven to 375 F.

Step 2 - On a cutting board, chop the pepperoni into small pieces.

pepperoni chopped into small pieces.

Step 3 - Slice the mozzarella into 2 long strips.

fresh mozzarella cut into two long pieces.

Step 4 - Combine the ground beef, chopped pepperoni, parsley, garlic, egg, Italian breadcrumbs, milk, seasoned salt, Italian seasoning, and black pepper together in a mixing bowl.

ground beef, chopped pepperoni, parsley, garlic, egg, Italian breadcrumbs, milk, seasoned salt, Italian seasoning, and black pepper together in a mixing bowl.

Step 5 - Divide the meat mixture into 4 equal amounts and form each into oval patties on wax paper.

Step 6 - Place the cheese strips in the middle of two of the meatloaf patties, divided evenly.

two long fresh mozzarella slices on two meatloaf patties.

Step 7 - Top each with another patty and seal the edges very well so that no cheese is exposed and they are shaped into two loaves. Some cheese may escape during baking anyway.

two pizza meatloaves ready to bake.

Step 8 - Place the two loaves onto a small rimmed baking sheet sprayed with non-stick spray and place in the oven. Bake for 40 minutes.

Step 9 - Remove the meatloaves from the oven and allow to rest for 10 minutes.

Step 10 - At the same time, add the pizza sauce to a small saucepan over medium heat. Cook until heated through, stirring occasionally.

Step 11 - Pour the warm pizza sauce on top of the meatloaves and serve.

Pepperoni Pizza Meatloaf and a side of garlic bread.
Pepperoni Pizza Meatloaf

Recipe FAQs

Can you add cheese to meatloaf?

Yes, you can add cheese to meatloaf. This flavorful easy Cheese Stuffed Pizza Meatloaf is packed with ooey-gooey fresh mozzarella cheese, making this a recipe you'll make again and again!

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Pepperoni Pizza Meatloaf and a side of garlic bread.

Pepperoni Pizza Meatloaf Recipe

This Pepperoni Pizza Meatloaf is a delicious ground beef meatloaf loaded with pizza seasonings, Pepperoni slices, and Italian bread crumbs, all wrapped around fresh mozzarella cheese and topped with warm pizza sauce.
4.50 from 4 votes
Prep Time 10 minutes
Cook Time 50 minutes
Rest Time 10 minutes
Total Time 1 hour 10 minutes
Course Beef
Cuisine American
Servings 2
Calories 642 kcal

Ingredients

  • ½ pound ground beef (or ground turkey, or ground chicken)
  • 10 pepperoni slices
  • 1 tablespoon chopped fresh parsley
  • ½ teaspoon jarred mince garlic
  • 1 egg
  • ¼ cup Italian breadcrumbs
  • cup milk
  • Tablespoon seasoned salt
  • 1 teaspoon Italian seasoning
  • teaspoon black pepper
  • 4 ounces fresh mozzarella cheese
  • 1 cup pizza sauce

Instructions
 

  • Preheat the oven to 375 F.
  • On a cutting board, chop the pepperoni into small pieces.
  • Slice the mozzarella into 2 long strips.
  • Combine the ground beef, chopped pepperoni, parsley, garlic, egg, Italian breadcrumbs, milk, seasoned salt, Italian seasoning, and black pepper together in a mixing bowl.
  • Divide the meat mixture into 4 equal amounts and form each into oval patties on wax paper.
  • Place the cheese strips in the middle of two of the meatloaf patties, divided evenly.
  • Top each with another patty and seal the edges very well so that no cheese is exposed and they are shaped into two loaves. Some cheese may escape during baking anyway.
  • Place the two loaves onto a small rimmed baking sheet sprayed with non-stick spray and place in the oven. Bake for 40 minutes.
  • Remove the meatloaves from the oven and allow to rest for 10 minutes.
  • At the same time, add the pizza sauce to a small saucepan over medium heat. Cook until heated through, stirring occasionally.
  • Pour the warm pizza sauce on top of the meatloaves and serve.

Notes

  • These meatloaves are very easy to make. We have also made enough for guests and everyone raves over them.
  • We make two individual loaves. If you want to make one loaf you may need to increase the baking time.

Nutrition

Serving: 1Calories: 642kcalCarbohydrates: 20gProtein: 41gFat: 44gSaturated Fat: 19gPolyunsaturated Fat: 2gMonounsaturated Fat: 17gTrans Fat: 2gCholesterol: 219mgSodium: 1845mgPotassium: 859mgFiber: 3gSugar: 7gVitamin A: 1272IUVitamin C: 12mgCalcium: 406mgIron: 5mg
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Hi and welcome. I’m Zona and I have a passion for recipes. I share recipes, tips, tricks, and resources to help you cook for two. Eat, drink, and enjoy!

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4.50 from 4 votes (4 ratings without comment)
Recipe Rating




Maggie

Wednesday 8th of February 2023

Your recipes and tips are excellent. I was thinking if you could advise things like suitability for freezing and also how long can be kept in fridge and how much of recipe can be pre prepared . Also, recipe quantities in metric would be great for us Aussies. It would all add to your already yummy easy recipes 😊