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Pepperoni Pizza Meatloaf

This Pepperoni Pizza Meatloaf is a delicious ground beef meatloaf loaded with pizza seasonings, Pepperoni slices, and Italian bread crumbs, all wrapped around fresh mozzarella cheese and topped with warm pizza sauce.

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Why I love this recipe

These meatloaves are very easy to make. We have also made enough for guests and everyone raves over them.

Pepperoni Pizza Meatloaf and a side of garlic bread.
Pepperoni Pizza Meatloaf

Ingredients

  • ground beef
  • pepperoni slices
  • chopped fresh parsley
  • jarred mince garlic
  • egg
  • Italian breadcrumbs
  • milk
  • seasoned salt
  • Italian seasoning
  • black pepper
  • fresh mozzarella cheese
  • pizza sauce

Substitutions

  • Substitute ground chicken or ground turkey for the ground beef.
  • You can stuff the meatloaf with shredded mozzarella but it may not melt as smoothly as fresh.

Step 1 – Preheat the oven to 375 F.

Step 2 – On a cutting board, chop the pepperoni into small pieces.

pepperoni chopped into small pieces.

Step 3 – Slice the mozzarella into 2 long strips.

fresh mozzarella cut into two long pieces.

Step 4 – Combine the ground beef, chopped pepperoni, parsley, garlic, egg, Italian breadcrumbs, milk, seasoned salt, Italian seasoning, and black pepper together in a mixing bowl.

ground beef, chopped pepperoni, parsley, garlic, egg, Italian breadcrumbs, milk, seasoned salt, Italian seasoning, and black pepper together in a mixing bowl.

Step 5 – Divide the meat mixture into 4 equal amounts and form each into oval patties on wax paper.

Step 6 – Place the cheese strips in the middle of two of the meatloaf patties, divided evenly.

two long fresh mozzarella slices on two meatloaf patties.

Step 7 – Top each with another patty and seal the edges very well so that no cheese is exposed and they are shaped into two loaves. Some cheese may escape during baking anyway.

two pizza meatloaves ready to bake.

Step 8 – Place the two loaves onto a small rimmed baking sheet sprayed with non-stick spray and place in the oven. Bake for 40 minutes.

Step 9 – Remove the meatloaves from the oven and allow to rest for 10 minutes.

Step 10 – At the same time, add the pizza sauce to a small saucepan over medium heat. Cook until heated through, stirring occasionally.

Step 11 – Pour the warm pizza sauce on top of the meatloaves and serve.

Pepperoni Pizza Meatloaf and a side of garlic bread.
Pepperoni Pizza Meatloaf

Recipe FAQs

Can you add cheese to meatloaf?

Yes you can add cheese to meatloaf. This flavorful easy Cheese Stuffed Pizza Meatloaf is packed with ooey-gooey fresh mozzarella cheese, making this a recipe you’ll make again and again!

Pepperoni Pizza Meatloaf and a side of garlic bread.
Yield: Serves 2

Pepperoni Pizza Meatloaf

Prep Time: 10 minutes
Cook Time: 50 minutes
Rest Time: 10 minutes
Total Time: 1 hour 10 minutes

This Pepperoni Pizza Meatloaf is a delicious ground beef meatloaf loaded with pizza seasonings, Pepperoni slices, and Italian bread crumbs, all wrapped around fresh mozzarella cheese and topped with warm pizza sauce.

Ingredients

  • 1/2 pound ground beef (or ground turkey, or ground chicken)
  • 10 pepperoni slices
  • 1 tablespoon chopped fresh parsley
  • 1/2 teaspoon jarred mince garlic
  • 1 egg
  • 1/4 cup Italian breadcrumbs
  • 1/8 cup milk
  • 1/8 Tablespoon seasoned salt
  • 1 teaspoon Italian seasoning
  • 1/8 teaspoon black pepper
  • 4 ounces fresh mozzarella cheese
  • 1 cup pizza sauce

Instructions

  1. Preheat the oven to 375 F.
  2. On a cutting board, chop the pepperoni into small pieces.
  3. Slice the mozzarella into 2 long strips.
  4. Combine the ground beef, chopped pepperoni, parsley, garlic, egg, Italian breadcrumbs, milk, seasoned salt, Italian seasoning, and black pepper together in a mixing bowl.
  5. Divide the meat mixture into 4 equal amounts and form each into oval patties on wax paper.
  6. Place the cheese strips in the middle of two of the meatloaf patties, divided evenly.
  7. Top each with another patty and seal the edges very well so that no cheese is exposed and they are shaped into two loaves. Some cheese may escape during baking anyway.
  8. Place the two loaves onto a small rimmed baking sheet sprayed with non-stick spray and place in the oven. Bake for 40 minutes.
  9. Remove the meatloaves from the oven and allow to rest for 10 minutes.
  10. At the same time, add the pizza sauce to a small saucepan over medium heat. Cook until heated through, stirring occasionally.
  11. Pour the warm pizza sauce on top of the meatloaves and serve.

Notes

  • These meatloaves are very easy to make. We have also made enough for guests and everyone raves over them.
  • We make two individual loaves. If you want to make one loaf you may need to increase the baking time.

Nutrition Information:

Yield:

2

Serving Size:

1

Amount Per Serving: Calories: 706Total Fat: 42gSaturated Fat: 19gTrans Fat: 1gUnsaturated Fat: 19gCholesterol: 251mgSodium: 1574mgCarbohydrates: 25gFiber: 4gSugar: 7gProtein: 54g

Nutrition information is a guideline only, is calculated automatically by third party software, and absolute accuracy is not guaranteed.

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Zona stirring food in a pan.

I’m Zona. My husband and myself are empty-nesters and parents of 1 adult son.  I have a passion for recipes and I share all the tips, tricks, and resources I can find (or create) to help you cook for two.

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