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Chicken and Broccoli Casserole with Mayo

This Chicken and Broccoli Casserole with Mayo is delicious, packed with tender chicken, cheese, and broccoli florets. The creamy sauce flavor is very close to homemade Alfredo.

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a Cheesy Chicken Broccoli Casserole in a baking dish.
Cheesy Chicken Broccoli Casserole for Two

Why I love this recipe

We love making this easy dish in individual portions for easy serving and cleanup, but you can also use a single 2-quart casserole dish. It makes a great Sunday dinner or busy weeknight meal.

This recipe is moderately low-carb, but not necessarily by Keto extreme low-carb guidelines.

Do you need a side dish to accompany it? We like brown rice, a side salad, and these easy homemade dinner rolls.

Expert Tips

You can use fresh broccoli florets or frozen broccoli. To switch it up, try green beans, diced cauliflower, or cauliflower rice.

You can use boneless chicken breasts or boneless chicken thighs. You could also use cooked chicken, leftover chicken, or rotisserie chicken, and lower the bake time to 30-35 minutes.

FAQ’s

Will it still turn out the same with fresh broccoli, as far as water content, or do you need to add water?

Hi Tee, you can substitute fresh broccoli for the frozen broccoli. Fresh broccoli will yield a bit longer cooking time than frozen. Also, the size you cut your broccoli will affect its cooking time as well. If you like your broccoli more on the softer side, cook it longer. 🙂

Can I use plain Greek yogurt in place of sour cream?

Yes, that should work fine.

Reader Comments

Marilyn – Thank you for this wonderful recipe. I need a low-sodium meal, and this is so delicious.

Process shots for Cheesy Chicken Broccoli Casserole

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a Cheesy Chicken Broccoli Casserole in a baking dish.

Chicken and Broccoli Casserole with Mayo Recipe

This Chicken and Broccoli Casserole with Mayo is incredibly creamy, delivering a flavor that rivals homemade alfredo. Plus, it’s both Low-Carb and Gluten-Free, making it a fantastic choice for those looking to enjoy a delicious meal without the extra carbs!
4.35 from 29 votes
Prep Time 5 minutes
Cook Time 45 minutes
Total Time 50 minutes
Course Chicken-Poultry
Cuisine American
Servings 2
Calories 580 kcal

Ingredients

  • 8 ounces diced boneless chicken
  • 2 cups chopped broccoli (fresh or frozen)
  • 2 ounces cream cheese, softened
  • ¼ cup sour cream (or greek yogurt)
  • cup mayonnaise (or light mayonnaise)
  • ¼ teaspoon garlic salt
  • ¼ teaspoon onion powder
  • teaspoon basil
  • teaspoon paprika
  • teaspoon thyme
  • 1 cup shredded cheese (like Monterey Jack, cheddar cheese, Colby, etc.)

Instructions
 

  • Preheat the oven to 375 degrees F. and spray two 18.6-ounce oven-safe dishes with non-stick cooking spray.
  • ​On a cutting board, cut the chicken into bite-sized cubes.
  • In a large bowl, combine all ingredients except the shredded cheese.
  • Pour the mixture into each prepared dish, divided evenly.
  • Bake for 40 minutes. 
  • Remove from the oven, top with the shredded cheese, and bake for 5 more minutes.

Notes

Notes about ingredients and substitutions
  • You can use fresh broccoli florets or frozen broccoli. To switch it up, try green beans, diced cauliflower, or cauliflower rice.
  • You can use boneless chicken breasts or boneless chicken thighs. You can also use cooked chicken, leftover chicken, or rotisserie chicken, and reduce the baking time to 30-35 minutes.
Storage instructions
  • Store leftovers in the fridge in an airtight container for 4-5 days.

Nutrition

Serving: 1Calories: 580kcalCarbohydrates: 10gProtein: 42gFat: 42gSaturated Fat: 18gPolyunsaturated Fat: 8gMonounsaturated Fat: 11gTrans Fat: 0.04gCholesterol: 168mgSodium: 989mgPotassium: 823mgFiber: 2gSugar: 4gVitamin A: 1598IUVitamin C: 80mgCalcium: 389mgIron: 1mg
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Hi, and welcome. I’m Zona, and I have a passion for recipes. I share recipes, tips, tricks, and resources to help you cook for two. Eat, drink, and enjoy!

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4.35 from 29 votes (28 ratings without comment)
Recipe Rating




Susan

Sunday 11th of August 2024

I replaced chicken with 2-5 oz cans of solid white tuna. One of my favorite meals is tuna casserole so this was a great substitute for a low carb version.

Zona House

Monday 12th of August 2024

Hi Susan, I love that idea. Thank you for your comment :)

Marilyn

Tuesday 22nd of August 2023

Thank you for this wonderful recipe. I need a low sodium meal and this is so delicious. The seond time I made the recipe it was dryer than the first. I wonder if adding a little water is OK?

Zona

Wednesday 23rd of August 2023

Hi Marilyn, yes water, milk, or extra sour cream should work if you want to add just a little more moistness. Thanks for your question :)

Michael Connolly

Monday 3rd of July 2023

Can I use plain Greek yogurt in place of sour cream?

Zona

Tuesday 4th of July 2023

Hi Michael, yes that should work fine. Thanks for your question :)

Tee

Friday 2nd of September 2022

Will it still turn out the same with fresh broccoli,as far as water content or do you need to add water?

Zona

Friday 2nd of September 2022

Hi Tee, you can substitute fresh broccoli for the frozen broccoli. Fresh broccoli will yield a bit longer cooking time than frozen. Also, the size you cut your broccoli will affect its cooking time as well. If you like your broccoli more on the softer side, cook it longer. Thanks for your question :)

Kristina Watson

Wednesday 30th of September 2020

This might be a stupid question as well but is the chicken cooked or raw? I can't tell from the pictures.

Zona

Wednesday 30th of September 2020

Hi Kristina, the chicken is raw and cut into bite-sized pieces. It will cook completely during the baking cycle. Enjoy :)