This Chicken and Broccoli Casserole with Mayo is delicious, packed with tender chicken, cheese, and broccoli florets. The creamy sauce flavor is very close to homemade Alfredo.
This recipe is moderately low-carb, but not necessarily by Keto extreme low-carb guidelines.
Why I love this recipe
We love making this easy dish in individual portions for easy serving and easy clean up, but you can also use a single 2-quart casserole dish. It makes a great Sunday dinner or busy weeknight meal.
Need a side dish to go with it? We like brown rice, a side salad, and these easy homemade dinner rolls.
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Ingredients
(amounts are listed in the recipe card at the bottom of the post)
boneless chicken
broccoli
cream cheese
sour cream
mayonnaise
garlic salt
onion powder
basil
paprika
thyme
shredded cheese
Substitutions
You can use fresh broccoli florets or frozen broccoli. To switch it up, try green beans, diced cauliflower, or cauliflower rice.
You can use boneless chicken breasts or boneless chicken thighs. You could also use cooked chicken, leftover chicken, or rotisserie chicken and lower the bake time to 30-35 minutes.
Equipment used for this recipe
- cutting board
- medium or large bowl
- two 18.6 ounce dishes or a 2-quart dish
How to make Chicken Broccoli Casserole
Step 1 - Preheat your oven to 375 degrees F. and spray two 18.6-ounce oven-safe casserole dishes with non-stick cooking spray.
Step 2 - On a cutting board, cut the chicken into small pieces.
Step 3 - In a large or medium bowl, combine all ingredients except the shredded cheese.
Step 4 - Pour the mixture into each baking dish, divided evenly.
Step 5 - Bake for 40 minutes.
Step 6 - Remove from the oven, add the shredded cheese on top of the chicken casserole, and bake for 5 more minutes.
Serve and Enjoy!
You may also enjoy
- Individual Broccoli Cheese Quiches
- Ham Broccoli Pasta Casserole
- Cold Broccoli Salad
- Chicken Pasta with Zucchini
- Sheet Pan Cauliflower
- 6 Ingredient Skillet Chicken and Broccoli
Chicken and Broccoli Casserole with Mayo Recipe
Equipment
Ingredients
- 8 ounces diced boneless chicken
- 2 cups chopped broccoli (fresh or frozen)
- 2 ounces cream cheese, softened
- ¼ cup sour cream
- ⅛ cup mayonnaise (or light mayonnaise)
- ¼ teaspoon garlic salt
- ¼ teaspoon onion powder
- ⅛ teaspoon basil
- ⅛ teaspoon paprika
- ⅛ teaspoon thyme
- 1 cup shredded cheese (like Monterey Jack, cheddar cheese, Colby, etc.)
Instructions
- Preheat oven to 375 degrees F. and spray two 18.6 ounce oven safe dishes with non-stick cooking spray.
- On a cutting board, cut the chicken into bite-sized cubes.
- In a large bowl, combine all ingredients except the shredded cheese.
- Pour the mixture into each prepared dish, divided evenly.
- Bake for 40 minutes.
- Remove from the oven, top with the shredded cheese, and bake for 5 more minutes.
Notes
- You can use fresh broccoli florets or frozen broccoli. To switch it up, try green beans, diced cauliflower, or cauliflower rice.
- You can use boneless chicken breasts or boneless chicken thighs. You could also use cooked chicken, leftover chicken, or rotisserie chicken and lower the bake time to 30-35 minutes.
Nutrition
Hi and welcome. I’m Zona and I have a passion for recipes. I share recipes, tips, tricks, and resources to help you cook for two. Eat, drink, and enjoy!
Susan
Sunday 11th of August 2024
I replaced chicken with 2-5 oz cans of solid white tuna. One of my favorite meals is tuna casserole so this was a great substitute for a low carb version.
Zona House
Monday 12th of August 2024
Hi Susan, I love that idea. Thank you for your comment :)
Marilyn
Tuesday 22nd of August 2023
Thank you for this wonderful recipe. I need a low sodium meal and this is so delicious. The seond time I made the recipe it was dryer than the first. I wonder if adding a little water is OK?
Zona
Wednesday 23rd of August 2023
Hi Marilyn, yes water, milk, or extra sour cream should work if you want to add just a little more moistness. Thanks for your question :)
Michael Connolly
Monday 3rd of July 2023
Can I use plain Greek yogurt in place of sour cream?
Zona
Tuesday 4th of July 2023
Hi Michael, yes that should work fine. Thanks for your question :)
Tee
Friday 2nd of September 2022
Will it still turn out the same with fresh broccoli,as far as water content or do you need to add water?
Zona
Friday 2nd of September 2022
Hi Tee, you can substitute fresh broccoli for the frozen broccoli. Fresh broccoli will yield a bit longer cooking time than frozen. Also, the size you cut your broccoli will affect its cooking time as well. If you like your broccoli more on the softer side, cook it longer. Thanks for your question :)
Kristina Watson
Wednesday 30th of September 2020
This might be a stupid question as well but is the chicken cooked or raw? I can't tell from the pictures.
Zona
Wednesday 30th of September 2020
Hi Kristina, the chicken is raw and cut into bite-sized pieces. It will cook completely during the baking cycle. Enjoy :)